Central Biorepository

The Central Biorepository (CBR) is a recharge-based core facility supporting collaboration among University of Michigan Medical School (UMMS) investigators by streamlining human biospecimen access, handling, processing, and compliance to accelerate biomedical research. Its services include: • Access to Biospecimens and Data: Researchers have access to hundreds of thousands of human biospecimens, each carefully annotated with clinical and research data. • Specimen Management: The CBR provides secure, monitored, and CAP-accredited storage for participating clinical research study teams using a Laboratory Information Management System (LIMS), LabVantage, for full traceability, data integration, and reporting. • Processing Services: Automated laboratory processing is performed using standardized and validated protocols to ensure specimen quality and reproducibility. • Collection Kit Logistics: For those participating clinical research study teams collecting human specimens, the CBR creates and ships custom specimen collection kits and coordinates biospecimen logistics. • Distribution and Shipping: The CBR manages controlled distribution and shipping of biospecimens to researchers and their collaborators as needed. • Regulatory Support: Assistance is provided for regulatory submission preparation to ensure compliance in research projects.

RRID

copy/paste for citations

University of Michigan Central Biorepository RRID:SCR_004643

Serving

U-M Researchers

Service Categories

Biorepository, Cancer Research, Cell-Based Research, Histology, Pathology, & Tissue, Human Research, Nucleic Acids

Contact

The CBR Team

[email protected]

Affiliation

Medical School

CFMS Website

Services

  • Cryogenic biospecimen storage, -196C LN2 vapor freezers
  • Ultra-low biosepcimen storage, -80C
  • Tissue Cassette Frozen Storage
  • FFPE Block Storage
  • Nitrogen Dessicator Cabinet Slide Storage
  • Glass Slide Storage (Room Temperature)
  • Standard Automated Aliquoting
  • Manual Viscous Biosample Aliquoting
  • Automated DNA Extraction from Whole Blood >2 ml
  • Automated DNA Extraction from Whole Blood or Buffy Coat <2 ml
  • Automated DNA Extraction from Oragene saliva collection tubes
  • Manual DNA Extraction from <500 ul whole blood
  • Manual DNA Extraction from FFPE tissue slides
  • Manual DNA Extraction cell-free biospecimens
  • Automated RNA Extraction from PaxGene RNA Whole Blood tubes
  • PBMC Isolation from CPT tubes of whole blood
  • PBMC Isolation from ACD tubes of whole blood
  • PBMC Isolation from EDTA tubes of whole blood
  • PicoGreen Quantification of DNA
  • Plasma or Serum Isolation from Whole Blood

Equipment

  • Cell Counter
  • Lonza FlashGel System
  • BioTek Microplate Reader
  • Light Microscope
  • Agilent TapeStation 4200
  • TECAN Automated Liquid Handler
  • QIAsymphony Liquid Handler
  • Revvity Automated Liquid Handler
  • Barcode Scanners, many
  • Clinical Centrifuges, QTY: 2
  • Clinical Centrifuge
  • Microcentrifuges
  • Cryoports, many
  • Cryofreezers, Liquid Nitrogen Vapor, -196C, QTY: 15
  • Ultra-low Freezers, -80C, QTY: 18
  • Cassette Printer
  • Label Printer, several
  • Nitrogen Dessicator Slide Storage Cabinet
  • Archival Slide Storage
  • MadgeTech Cryo-Temp Data logger, QTY: 15
  • MadgeTech RTD Data Logger
  • MadgeTech RTD Probes, QTY: 10
  • TempTrak Probes and Tranmitters QTY: 57 ea
  • Biosafety Cabinet, QTY:3