Center for Structural Biology (CSB)

assists with protein engineering, purification, and macromolecular crystallization for solving crystal structures.

Contacts

Ashley Schork
734-647-8098
lsi-structure@umich.edu

Clay Brown, PhD
734-615-5679

Jeanne Stuckey, PhD
734-647-7534

Location

Mary Sue Coleman Hall (LSI - Rm 3258)
210 Washtenaw Ave, Ann Arbor, MI

Affiliations
Life Sciences Institute

Who We Serve

University of Michigan Researchers and External Researchers

Core Summary

The Center for Structural Biology (CSB), housed in the Life Sciences Institute, is a comprehensive structural biology resource for researchers at the University of Michigan and surrounding areas.

The CSB includes a high-throughput protein laboratory for protein engineering, protein purification facilities for small- and large-scale protein production, macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules, and an X-ray facility with access to high energy synchrotron radiation. Our dedicated staff scientists have years of academic and industry experience, allowing us to provide expert guidance to researchers through every stage of a project — collaborating and consulting with researchers who use the facilities. We also have a programmatic collaboration with the LSI’s Center for Chemical Genomics, allowing the determination of target proteins in complex with compounds identified in high-throughput screening.

Service Categories: Chemical, Material and Protein Characterization Service Categories: Molecular Biology

Services

Cloning

Crystallization

Differential thermal analysis

Drug development

Instrument/Facility usage

NMR
Small molecule,

or full service

PCR

Protein crystallography

Protein engineering

Protein production

Structure determination

Xray


Equipment

Isothermal calorimeter
NanoITC, Quant Studio 7,

PCR
Quant Studio 7,

Protein kinetics
Octet Red,