The Center for Structural Biology (CSB), housed in the Life Sciences Institute, is a comprehensive structural biology resource for researchers at the University of Michigan and surrounding areas.

The CSB includes a high-throughput protein laboratory for protein engineering, protein purification facilities for small- and large-scale protein production, macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules, and an X-ray facility with access to high energy synchrotron radiation. Our dedicated staff scientists have years of academic and industry experience, allowing us to provide expert guidance to researchers through every stage of a project — collaborating and consulting with researchers who use the facilities. We also have a programmatic collaboration with the LSI’s Center for Chemical Genomics, allowing the determination of target proteins in complex with compounds identified in high-throughput screening.