BRCF Transgenic Animal Model Core

provide access to transgenic animal technology in an efficient, effective manner.


Elizabeth Hughes, MS

Zachary T Freeman DVM, PhD


MSRB II (Rm 2570)
1150 W. Medical Center Dr, Ann Arbor, MI

Medical School

Who We Serve

University of Michigan Researchers and External Researchers

Core Summary

The mission of the BRCF Transgenic Core is to provide access to transgenic animal technology in an efficient, effective manner. The Core routinely uses CRISPR/Cas9 to produce gene edited mice and rats. The Core delivers transgenic mice and rats to investigators for study. Researchers can use Core laboratory space and equipment side by side with Core staff. The Core consults on all phases of genome editing (CRISPR/Cas9), transgenic, and gene targeting research from experimental design through production and breeding. If desired, the investigator can simply name the required genetic change to be introduced; the Core will take all necessary steps to produce the necessary animals for the investigator. The Core’s expertise and success in genetic engineering with CRISPR/Cas9 means that the investigator can focus resources on research results instead of investing in equipment and training in new methods. The efficiency of transgenic mouse and rat model production in the Transgenic Core meets or exceeds standards in the published literature. Nearly 1000 research papers based on the use of mouse and rat models produced in the Core have been published.

Service Categories: Animal Research; Education and Training ; Molecular Biology


  • CRISPR/Cas9

  • Embryo cryopreservation/recovery

  • ES cell
    De novo cell line production, Gene targeting, Mouse chimera production,

  • IVF

  • Sperm cryopreservation

  • Transgenic animals


No items found