Pharmacokinetic and Mass Spectrometry Core

maintains mass spectrometry instruments and the technical expertise to design quantitative assays for drug-like compounds.

Contacts

Bo Wen, PhD
734-615-3470
wenb@med.umich.edu

Location

NCRC Building 520 (Rm 3400)
1600 Huron Parkway, Ann Arbor, MI

Affiliations
Pharmacy

Who We Serve

University of Michigan Researchers and External Researchers

Core Summary

We help researchers make informed decisions about the discovery, development, and refinement of therapeutics. Our facility maintains state-of-the-art mass spectrometry instruments and the technical expertise to design quantitative assays for drug-like compounds to aid lead optimization. We perform pre-clinical studies for investigators to answer key questions such as oral bioavailability, plasma protein binding, tissue biodistribution, and metabolite identification by doing quantitative LC-MS analysis of molecules and mass spectrometry imaging of spatial localization biomarkers in tissue section. We also support translation of exposure-response relationships in preclinical disease models to aid dose justification and drug repurposing considerations.  Clinical pharmacokinetic (PK) studies that require bioanalysis, optimal sampling time determination, sample handling and storage, and data analysis (non-compartmental, compartmental, population-PK) are also supported.

Service Categories: Animal Research Service Categories: Chemical, Material and Protein Characterization Service Categories: Human Research Service Categories: Molecular Biology

Services

Advanced mass spectrometry application
Biomarker identification and characterization, Mass spectrometry imaging on tissue samples, Targeted lipidomics, Targeted metabolomics,

Clinical Pharmacokinetic studies
Clinical study development, Data analysis with non-compartment model, Modeling with Population-PK analysis, Precision medicine,

In vitro and In vivo ADME
Customer designed animal PK study, Cytochrome P450 inhibition, induction, In vivo complete PK study, In vivo PK screening study, Max tolerated dose, Metabolite identification, Microsomal, Plasma, S9, Hepatocyte stability, Oral bioavailability of drugs, Plasma protein binding, Tissue bioanalysis,

LCMS bioanalysis
Bioanalysis for clinical study, Bioanalysis method development, Chemical compound identification, Drug and metabolite analysis, Method transfer and method qualification, Quantitative analysis,


Equipment

Agilent 1200 HPLC

HTX TM- Matrix Sprayer

Leica CM 1950 Cryostat

Mass spectrometer
AB Sciex 3200 QTRAP, AB Sciex 4000 QTRAP, AB Sciex 4500 QTRAP, AB Sciex 5500 QTRAP, Sciex X500R Qtof High Resolution, Waters SYNAPT G2 Si HDMS Qtof with MALDI, Waters Xevo TQ-D,

Precellys Evolution Homogenizer

Shimadzu 20A HPLC

Water ACQUITY H-Class UPLC