Natural Products Discovery Core (NPDC)

develops candidates identified through high-throughput screening into unique, bioactive, patentable, small molecules.

Contacts

Ashootosh Tripathi, PhD
734-647-9466
natprodcore@umich.edu

Location

Mary Sue Coleman Hall (LSI - Rm 4314A)
210 Washtenaw Ave, Ann Arbor, MI

Affiliations
Life Sciences Institute

Who We Serve

University of Michigan Researchers and External Researchers

Core Summary

The University of Michigan Natural Products Discovery Core (NPDC) has developed a 40,000-sample (and growing) library of natural product extracts derived from a unique collection of diverse marine and terrestrial actinomycetes, fungi and cyanobacteria.  The core provides researchers at U-M and external partners with the technology and expertise to develop candidates identified through high-throughput screening into unique, bioactive, patentable, small molecules.  Our rapid genomic and metabolomic profiling capabilities allow users to identify high value molecules as probes and drug leads.

Service Categories: Chemical, Material and Protein Characterization Service Categories: Molecular Biology

Services

Assay development and optimization

Biocatalysis

Bioinformatics analysis
Microbial Genome Assembly,

Chromatography

Drug discovery

High-throughput screening

Mass spectrometry
LC-MS, LC-MS/MS, qTOF, Rapid-fire 365,

Metabolite identification
Small molecule,

Microbial cultivation

Natural product extracts

NMR
1D Experiments, 2D Experiments, Small molecule,

Sample processing
Drying equipment,

Spectroscopy

Structure determination
Small molecule,

Untargeted Metabolomics
Secondary metabolites,


Equipment

Drying equipment
Biotage SPE Dry 96 Dual Sample Concentrator System, Biotage V10 Touch with/without Gilson Handlers, Buchi Syncore Analyst, ThermoSavant SpeedVac,

Flash Chromatography
Biotage Selekt 2 channel extended bed UV/Vis,

Incubators
Shake culture/orbital incubator shaker facility (MAXq8000 and alike),

Liquid Handler
Gilson GX 271 ASPEC with Dual Syringe Pump,

Mass spectrometer
Agilent 6545Q-TOF LC-MS with RapidFire 365 High-throughput, Shimadzu LCMS 2020 with dual ESI/APCI probe (both +ve/-ve mode),

NMR
600 MHz NMR with Prodigy Probe,

Thermo KingFisher Flex high throughput DNA and protein purification system