Natural Products Discovery Core
The LSI's Natural Products Discovery Core has developed a 55,000-sample (and growing) library of natural product extracts derived from a unique collection of diverse marine and terrestrial actinomycetes, fungi and cyanobacteria. The core provides researchers at U-M and external partners with the technology and expertise to develop candidates identified through high-throughput screening into unique, bioactive, patentable, small molecules.
RRID
copy/paste for citations
University of Michigan Natural Products Discovery Core RRID:SCR_023105
Serving
External Researchers, U-M Researchers
Service Categories
Assay Development, Biorepository, Cancer Research, Chemical Characterization, Drug Discovery & Pharmacology, Education and Training, Informatics, Statistics & Computation, Mass Spectrometry,
Affiliation
Life Sciences Institute
Services
- Microbial & Extract Libraries
- Genome Mining and Bioinformatics
- Post-Screening Follow-Up
- Chemical Enrichment and Profiling
- Large Scale Culture and Optimization
- E-PuRE Platform-Guided Isolations
- Dereplication, Structure Elucidation, Chemical Derivatization
- Yield Optimization and Mutasynthesis
- Integrated Virtual Discovery and On-Demand Natural Products Library (vMCE Platform)
Equipment
- Shimadzu Preparative HPLC System
- Biotage Isolera Selekt
- Distek BIOne 1250 Dual Bioreactor/Fermentation
- RapidFire 365 High-throughput MS system
- Agilent 6546 LC/Q-TOF
- Assist Plus (plating robot)
- Shimadzu HPLC with ELSD detector and autosampler
- Shimadzu HPLC with autosampler semi-preperative
- Mediajet plate pourer
- LCMS