Michigan Integrative Musculoskeletal Health Core Center (MiHMC)

provides analyses aimed at understanding musculoskeletal health.


Karl Jepsen, PhD



School of Dentistry
1011 N University Ave, Ann Arbor, MI

109 Zina Pitcher Place, Ann Arbor, MI

Dentistry, Medical School

Who We Serve

University of Michigan Researchers and External Researchers

Core Summary

The theme of the Michigan Integrative Musculoskeletal Health Core (MiMHC) Center is understanding mechanisms of musculoskeletal health, injury, and disease across the lifespan. The MiMHC supports three Resource Cores: Histological Assessment Core, Structural and Compositional Assessment Core, and the Functional Assessment Core. There are over 100 faculty members of the MiMHC; these investigators plus their research teams together make Michigan a highly productive and collaborative environment to conduct MSK research!

Service Categories: Animal Research Service Categories: Data Tools and Analysis Service Categories: Education and Training Service Categories: Engineering Service Categories: Histology, Pathology and Tissue Service Categories: Human Research Service Categories: Imaging Service Categories: Informatics, Statistics and Computation


Functional Assessment Core
Bone Testing, Custom Fabrication/Machining, Fracture Healing/Surgical Models, Microsurgery Models, Muscle Mechanics, Tendon (Soft Tissue) Testing, Whole Animal Testing,

Histological Assessment Core
Access to Specialized Equipment for Sectioning and Staining, Cryosectioning, Histology Services, Histomorphometry/Microscope Image Analysis, Plastic/Paraffin Embedding,

Structural and Compositional Assessment Core
Image Analysis, Micro-Computed Tomography (in vivo & ex vivo), Nano-Computed Tomography (ex vivo), Raman Spectroscopy,


Functional Assessment Core
Alzet minipumps, Biomechanics and Motion Capture Facilities, Blood collection equipment, Bose Electroforce 3300 AT Test Instrument, Epuipment for Tendon/Soft Tissue testing, Fluorescence-guided nanoindentation, Instron 5500R servo-electric materials testing system, Instron 8511 Servohydraulic Uniaxial Testing System, Specialized micro-material testing systems for static and fatigue evaluation, Ultrasound and Laser Doppler imaging,

Histological Assessment Core
Bioquant Image analysis software, Buehler Automet 300 Grinder, Complete embedding and preparation equipment and supplies for paraffin and plastic embedding of biologic specimens, Cryostat, Exact diamond band saws, Microtome, Nikon Eclipse microscope, Slow speed diamond saws,

Structural and Compositional Assessment Core
Bruker/Skyscan 1176 High Resolution in vivo micro-CT imaging system, GE eXplore Locus SP ex vivo micro-CT, GE phoenix nanotom-M ex vivo nano-CT, HP Engineering Workstations for image analysis, Raman spectroscopy, Scanco uCT 100 ex vivo micro-CT,