BRCF Metabolomics Core

measures concentrations of small molecules in biological samples on a recharge basis.

Contacts

Maureen Kachman, PhD
734-232-0842
mkachman@umich.edu

Location

6120 Brehm Tower
1000 Wall St, Ann Arbor, MI

Affiliations
Medical School

Who We Serve

University of Michigan Researchers

Core Summary

The BRCF Metabolomics Core measures concentrations of small molecules in biological samples on a recharge basis. We strive to provide GLP-quality analytical services at competitive prices, and regularly customize assays to fit our clients’ needs. Services include initial consultation, method development, data collection, interpretation, and presentation. Core competencies include both targeted assays for many analyte classes as well as untargeted assays to evaluate the entire metabolome in biofluids and tissues, measurement of flux through various pathways using 13C-isotopomer analyses, and structural identification of isolated unknowns and potential biomarkers.

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Services

Bioinformatics analysis

D4-Steroids

Method Development

Non-targeted Metabolomics

Shotgun Lipidomics (Non-targeted Lipidomics)

Stable Isotope Labelling (Fluxomics) of any existing targeted assay

Statistics

Targeted Assays
Acylcarnitines, Amino Acids, Bile Acids, Eicosanoids, Glycolysis/TCA, Short Chain Fatty Acids,


Equipment

Mass spectrometer
2D-LC-MS, GC-MS, High sensitivity triple-quad instruments for LC-MS, Ion-Pairing LC-MS, Multiple high-resolution, high mass accuracy qTOF,