Biomolecular Nuclear Magnetic Resonance Laboratory

uses state of the art NMR instruments to obtain structural, dynamic and kinetic information on biological macromolecules.

Contacts

Debashish Sahu, PhD
734-647-3872
bionmrcore@umich.edu

Location

Chemistry Building (Rm 1047 & 2060)
930 N. University Ave, Ann Arbor, MI

Mary Sue Coleman Hall (LSI - Rm 3214)
210 Washtenaw Ave, Ann Arbor, MI

Affiliations
Literature, Science and the Arts

Who We Serve

University of Michigan Researchers and External Researchers

Core Summary

The Biomolecular Nuclear Magnetic Resonance (Biomolecular NMR) Laboratory uses state of the art NMR instruments, providing the ability to obtain structural, dynamic and kinetic information on biological macromolecules including protein, RNA and DNA.  Automated sampling devices also make it ideal for metabolomics and high throughput data collection.

Service Categories: Imaging

Services

Dynamics of biomolecules

Monitoring drug stability over time

NMR
One-on-one training on NMR operation and data interpretation,

Protein, RNA and DNA structure elucidation

Quantitation of soluble materials

Real-time kinetics reaction monitoring

Structure analysis report

Structure identification of drug metabolites, impurities, degradants and unknowns

Study of dynamics and structure of drug-receptor interactions

Verification of structures of drugs and reference compounds


Equipment

Bruker 600 CP NMR spectrometer

Data analysis software
CYANA 2.0, MNova, NMRFAM-Sparky, NMRViewJ, Topspin 4, VNMRJ,

NMR
Agilent 400 NMR spectrometer, Agilent 600 CP NMR spectrometer, Agilent 600 NMR spectrometer, Bruker 800 CP NMR spectrometer,