Biomolecular Nuclear Magnetic Resonance Laboratory

uses state of the art NMR instruments to obtain structural, dynamic and kinetic information on biological macromolecules.

Contacts

Debashish Sahu, PhD
734-647-3872
bionmrcore@umich.edu

Location

Chemistry Building (Rm 1047 & 2060)
930 N. University Ave, Ann Arbor, MI

Mary Sue Coleman Hall (LSI - Rm 3214)
210 Washtenaw Ave, Ann Arbor, MI

Affiliations
Literature, Science and the Arts

Who We Serve

University of Michigan Researchers and External Researchers

Core Summary

The Biomolecular Nuclear Magnetic Resonance (Biomolecular NMR) Laboratory uses state of the art NMR instruments, providing the ability to obtain structural, dynamic and kinetic information on biological macromolecules including protein, RNA and DNA.  Automated sampling devices also make it ideal for metabolomics and high throughput data collection.

Service Categories: Imaging

Services

  • Dynamics of biomolecules

  • Monitoring drug stability over time

  • NMR
    One-on-one training on NMR operation and data interpretation,

  • Protein, RNA and DNA structure elucidation

  • Quantitation of soluble materials

  • Real-time kinetics reaction monitoring

  • Structure analysis report

  • Structure identification of drug metabolites, impurities, degradants and unknowns

  • Study of dynamics and structure of drug-receptor interactions

  • Verification of structures of drugs and reference compounds


Equipment

  • Agilent/Varian 400 MHz w/room temperature probe (H/F-X) 400 MHz NMR
    Bruker, Equipment Available For Use
  • Bruker 600 MHz w/cryoprobe (H/C/N) 600MHz NMR
    Bruker, Equipment Available For Use
  • Bruker 600 MHz w/prodigy cryoprobe (H/F-X) 600 MHz NMR
    Bruker, Equipment Available For Use
  • Bruker 800 MHz w/cryoprobe (H/C/N) 800MHz NMR
    Bruker, Equipment Available For Use