Natural Products Discovery Core (NPDC)
develops candidates identified through high-throughput screening into unique, bioactive, patentable, small molecules.
Contacts
Ashootosh Tripathi, PhD
734-647-9466
natprodcore@umich.edu
Jenn Soules
734-647-7772
jlsoules@umich.edu
Location
Mary Sue Coleman Hall (LSI - Rm 4314A)
210 Washtenaw Ave, Ann Arbor, MI
Life Sciences Institute
Who We Serve
University of Michigan Researchers and External Researchers
Core Summary
The University of Michigan Natural Products Discovery Core (NPDC) has developed a 50,000-sample (and growing) library of natural product extracts derived from a unique collection of diverse marine and terrestrial actinomycetes, fungi and cyanobacteria. The NPDC provides researchers at U-M and external partners with the technology and expertise to develop candidates identified through high-throughput screening into unique bioactive, patentable small molecules. Our rapid genomic and metabolomic profiling capabilities allow users to identify high-value molecules as probes and drug leads.
Services
- Assay development and optimization
- Biocatalysis
- Bioinformatics analysis
Microbial Genome Assembly,
- Chromatography
HPLC purification,
- Drug discovery
- High-throughput screening
- Mass spectrometry
LC-MS, LC-MS/MS, qTOF, Rapid-fire 365,
- Metabolite identification
Small molecule,
- Microbial cultivation
- Natural product extracts
- NMR
1D Experiments, 2D Experiments, Small molecule,
- Sample processing
Drying equipment,
- Spectroscopy
- Structure determination
Small molecule,
- Untargeted Metabolomics
Secondary metabolites,
Equipment
- 600 MHz NMR with Prodigy Probe
- Agilent 6545Q-TOF LC-MS with RapidFire 365 High-throughput
- Biotage Selekt 2 channel extended bed UV/Vis
- Biotage SPE Dry 96 Dual Sample Concentrator System
- Biotage V10 Touch with/without Gilson Handlers
- Buchi Syncore Analyst
- Gilson GX 271 ASPEC with Dual Syringe Pump
- Shake culture/orbital incubator shaker facility (MAXq8000 and alike)
- Shimadzu LCMS 2020 with dual ESI/APCI probe (both +ve/-ve mode)
- Thermo KingFisher Flex high throughput DNA and protein purification system
- ThermoSavant SpeedVac