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Single Molecule Analysis in Real-Time (SMART) Center

The SMART (Single Molecule Analysis in Real-Time) Center is an NSF-seeded, shared-use facility providing university researchers with single molecule detection and manipulation tools to track and analyze biomolecules with unprecedented detail.  The SMART Center provides access to state-of-the art instrumentation, including single molecule spectroscopy and imaging, laser tweezers, and atomic force microscopy; as well as experienced support in experimental planning and analysis.  We would also be happy to give your group a short demonstration of our capabilities and discuss potential applications.

Areas of Expertise

  • Single molecule techniques
  • Fast high-resolution fluorescent imaging
  • Single particle fluorescent tracking
  • Fluorescence lifetime imaging
  • Force spectroscopy
  • Experimental planning
  • Single molecule data analysis
  • Training
  • Single molecule localization (STORM)

Who We Serve

University of Michigan and external academic & commercial researchers

Contacts

Damon Hoff
734-763-5449
hoffj@umich.edu

Location

Chemistry, Rm 3080
930 N University Ave
Ann Arbor, MI 48109

Affiliations

Literature, Science and the Arts

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Services

  • Fluorescence fluctuation spectroscopy
  • Fluorescent lifetime
  • Force spectroscopy
    • Atomic force microscopy
    • Optical tweezers
  • Imaging
    • Atomic force microscopy
    • Single molecule fluorescent imaging and tracking
  • Microscopy
    • Atomic force microscopy
    • Single molecule fluorescent imaging and tracking
    • Super-resolution
  • Training

Additional Services

Assistance with:

  • Experimental planning
  • Data acquisition
  • Data analysis

Equipment

  • Atomic Force Microscopy
    • AFM Workshop TT-AFM atomic force microscope
  • Confocal Microscope
    • ISS Alba time-resolved confocal microscope
  • Microscope
    • TIRF / HILO fluorescence microscope with multicolor EMCCD cameras
  • Optical tweezers
    • MiniTweezers
    • Single Particle Nanomanipulator + fluorescence microscope
  • Software
    • Image analysis and particle tracking software
  • Super Resolution Microscope
    • TIRF / HILO fluorescence microscope with multicolor EMCCD cameras

FAQs