Central Biorepository
The Central Biorepository (CBR) is a recharge-based core facility supporting collaboration among University of Michigan Medical School (UMMS) investigators by streamlining human biospecimen access, handling, processing, and compliance to accelerate biomedical research. Its services include: • Access to Biospecimens and Data: Researchers have access to hundreds of thousands of human biospecimens, each carefully annotated with clinical and research data. • Specimen Management: The CBR provides secure, monitored, and CAP-accredited storage for participating clinical research study teams using a Laboratory Information Management System (LIMS), LabVantage, for full traceability, data integration, and reporting. • Processing Services: Automated laboratory processing is performed using standardized and validated protocols to ensure specimen quality and reproducibility. • Collection Kit Logistics: For those participating clinical research study teams collecting human specimens, the CBR creates and ships custom specimen collection kits and coordinates biospecimen logistics. • Distribution and Shipping: The CBR manages controlled distribution and shipping of biospecimens to researchers and their collaborators as needed. • Regulatory Support: Assistance is provided for regulatory submission preparation to ensure compliance in research projects.
RRID
copy/paste for citations
University of Michigan Central Biorepository RRID:SCR_004643
Serving
U-M Researchers
Service Categories
Biorepository, Cancer Research, Cell-Based Research, Histology, Pathology, & Tissue, Human Research, Nucleic Acids
Services
- Cryogenic biospecimen storage, -196C LN2 vapor freezers
- Ultra-low biosepcimen storage, -80C
- Tissue Cassette Frozen Storage
- FFPE Block Storage
- Nitrogen Dessicator Cabinet Slide Storage
- Glass Slide Storage (Room Temperature)
- Standard Automated Aliquoting
- Manual Viscous Biosample Aliquoting
- Automated DNA Extraction from Whole Blood >2 ml
- Automated DNA Extraction from Whole Blood or Buffy Coat <2 ml
- Automated DNA Extraction from Oragene saliva collection tubes
- Manual DNA Extraction from <500 ul whole blood
- Manual DNA Extraction from FFPE tissue slides
- Manual DNA Extraction cell-free biospecimens
- Automated RNA Extraction from PaxGene RNA Whole Blood tubes
- PBMC Isolation from CPT tubes of whole blood
- PBMC Isolation from ACD tubes of whole blood
- PBMC Isolation from EDTA tubes of whole blood
- PicoGreen Quantification of DNA
- Plasma or Serum Isolation from Whole Blood
Equipment
- Cell Counter
- Lonza FlashGel System
- BioTek Microplate Reader
- Light Microscope
- Agilent TapeStation 4200
- TECAN Automated Liquid Handler
- QIAsymphony Liquid Handler
- Revvity Automated Liquid Handler
- Barcode Scanners, many
- Clinical Centrifuges, QTY: 2
- Clinical Centrifuge
- Microcentrifuges
- Cryoports, many
- Cryofreezers, Liquid Nitrogen Vapor, -196C, QTY: 15
- Ultra-low Freezers, -80C, QTY: 18
- Cassette Printer
- Label Printer, several
- Nitrogen Dessicator Slide Storage Cabinet
- Archival Slide Storage
- MadgeTech Cryo-Temp Data logger, QTY: 15
- MadgeTech RTD Data Logger
- MadgeTech RTD Probes, QTY: 10
- TempTrak Probes and Tranmitters QTY: 57 ea
- Biosafety Cabinet, QTY:3